Ongoing Clinical Projects 2018-2019

Aravind Eye Hospitals & Postgraduate Institute of Ophthalmology
Cataract & IOL Services
  • The natural history of IOL in eyes with exfoliation syndrome
  • Visual performance comparison between phacoemulsification and manual small incision cataract surgery in eyes with senile cataract: a prospective randomised clinical trial
  • Prostaglandin level estimation in phacoemulsification and Femtosecond laser assisted cataract surgery with and without NSAID and correlation with postoperative inflammation and cystoid macular edema
  • Visual Outcomes of SMART SICS
  • Multicentre, single arm, observational post market clinical follow-up evaluation of posterior capsular opacification, intraocular lens  glistening and visual outcome in patients implanted with hoya vivinextm isert® IOL in routine clinical practice
  • Surgical outcome comparison of miniCAP Vs Phacoemulsification: A Randomised controlled trial
  • To compare the stability of Iris fixated IOL between  3 piece PMMA  and single piece IOL with modified haptics
  • A prospective, multicentric, randomized controlled, study on long term outcomes of Phacoemulsification with Intraocular lens implantation in pseudo exfoliation syndrome patients
  • A prospective, non-randomized, single arm, open label Study to evaluate the efficacy of multifocal intraocular lenses with patients having cataract in both eyes
  • Visual performance comparison between phacoemulsification and manual small incision cataract surgery in eyes with senile  cataract: A prospective randomised clinical trial
  • Determining the quantitative and qualitative effects of pre and per-operative music listening on a patient’s experience of cataract surgery
  • Complications and visual outcomes in miniCAP and phacoemulsification cataract surgeries performed by trainee ophthalmologists: A Multicentre randomised controlled trial
  • Cost benefit analysis for patients undergoing femtosecond laser assisted cataract surgery and conventional phacoemulsification with aspheric IOLs in both eyes
  • Assessing the clinical outcome of femtosecond assissted laser surgery versus clear corneal phacoemulsification in three groups of pre-operative astigmatism: A retrospective study
Cornea
  • Assessment of tear film alterations in post cataract surgery patients
  • Comparative study on different methods of eye drop counselling in post optical keratoplasty patients
  • Knowledge and awareness regarding eye donation- A survey
  • Microbiological and clinical outcomes of corneal collagen crosslinking (CXL) in bacterial keratitis –  A randomized control trial
  • Comparison of fibrin glue vs. sutures in lamellar corneal tear repair
Glaucoma
  • Deep learning algorithms applied to optical coherence tomography images of the optic nerve head for improved glaucoma diagnosis
  • Indian childhood glaucoma incidence study
  • Perfusion loss assessment in glaucoma
  • Prospective study of changes in ocular biometrics after trabeculectomy with mitomycin C in adult glaucoma patients
  • Blindness due to steroid induced glaucoma in children in India
  • Prospective study of changes in ocular biometrics after trabeculectomy with mitomycin C in adult glaucoma patients
  • Shared medical appointments randomized trial
  • A prospective study to evaluate the reasons for hospital visit among patients with primary glaucoma
  • The Asia Primary Tube versus Trab Study
Neuro Ophthalmology
  • A phase 2/3, randomised, double-masked, shamcontrolled trial of qpi-1007 delivered by single or multi-dose intravitreal injections to subjects with acute non arteritic anterior ischemic optic neuropathy
Orbit
  • Genetic and transcript analysis of RB1 gene in south Indian retinoblastoma patients
  • Identification and validation of deregulated cancer pathways in retinoblastoma
  • Translational genomics of paediatric eye diseases
  • Translational genomics of ocular cancers
Paediatric Ophthalmology
  • Analysis of the characteristics and etiological factors of headache among various age group of paediatric patients presenting to tertiary eye care centre
  • Evaluation of etiology in children presenting with cataract to 4 tertiary eye hospitals in south India
  • Heritability and clinical profile of myopia in children in a tertiary care hospital: A cross sectional study
  • Correlation between handedness and ocular dominance in strabismic amblyopia
  • Long term outcomes of Ectopialentis managed with Cionni CTR placement in paediatric patients
  • Atropine 0.01% dose for the treatment of progressive myopia
  • RoP Long term followup study
  • Assessment of reading visual acuity in patients with nystagmus
  • Translational genomics of paediatric eye diseases
  • Management of Nystagmus
  • Referral uptake and outcome in children referred to tertiary care centre from school screening camps
  • Comparison of refractive measurement with E-see autorefractometer & standards cycloplegic retinoscopy
  • Normative data for functional vision assessment in typically developing children
  • Retinitis Pigmentosa in children; epidemiological characteristics and ERG changes: a population based study in south India
  • Etiology of paediatric cataract
  • Ocular motility evaluation in patients undergoing Aurolab AADI implantation
  • Utility of +1.5D test at screen level
  • Residual vision impairment among students from school for the blind
  • Yoke prism trial
Retina
  • Automated detection algorithm assisted read  study – Vision centres
  • An extension study to evaluate the long term efficacy and safety of Ranibizumab compared with laser therapy for the treatment of infants born prematurely with retinopathy of prematurity
  • Statistical modelling and risk assessment of type 2 diabetes complications in india
  • Validation of neuropupillary index (npi) measured by automated Neuroptics PLR-3000 pupillometer in diagnosing ocular pathologies in south Indian population
  • Structured post-marketing surveillance to collect the safety data of intravitreal aflibercept injection (IVT-AFL) in patients of wet age-related macular degeneration during real world clinical practice
  • ROP Tele screening
  • Optos Vs Clarus with Pupillometry
  • A phase III randomisd, double-masked, parallel group, multicentre study to compare the efficacy, safety, pharmacokinetics and immunogenicity between sb11 (proposed ranibizumab biosimilar) and lucentis in subjects with neovascular age-related macular degeneration
  • A two –year, two –arm, randomised, double-masked, multicentre, phase III study assessing the efficacy and safety of brolucizumab versus aflibercept in adult patients with visual impairment due to diabetic macular edema
  • Translating research into clinical and community practice: a multi-state, multi-centre statistical modelling of risk-based stratified and personalised screening for complications of diabetes in India
  • Conventional versus Inverted Flap Technique for large macular holes: A Prospective randomised control trial
  • Effect of pachychoroid features on visual and functional outcomes in polypoidal choroidal vasculopathy
  • Routine fundus photography for screening of posterior segment disease in patients visiting vision centres
  • Prevalence and morphological characteristics of dome shaped macula in myopic eyes on enhanced depth imaging spectral-domain optical coherence tomography
  • Subjective High-risk patient counselling Randomisation Project
  • A study on the differential expression of Piwiinteracting RNAs (piRNA) and altered Piwi-like protein interactions in Diabetic Retinopathy
Uvea
  • Macular Edema Nepafenac vs. Difluprednate (MEND) Uveitis Trial
  • Leptospirosis – ICMR survey